Lihong Wang, M.D., Ph.D.[Edit Page]
Assistant Professor, Psychiatry
MD, Ph D, 1999, Yokoham City Uni School of Medicine (Neurology)
Research Interests
Emotion, Executive function, Mood disorders, Cogntive impairments, Parkinson's disease and Parkinsonian Syndrome, fMRI and MEG/EEG
Research Statement
I am interested in using neuroimaging techniques to study prefrontal function, in particular, neural substrates associated with emotional processing and the interaction of emotion and executive function. I study healthy populations (adolescents, young adults, and old adults) and clinical populations with neuropsychiatric diseases (depression, PTSD) or neurological diseases (Parkinson's disease, MCI) to characterize their alterations in emotion and cognitve function.
Currently, my studies focus on investigating neural mechanism of depression using a combination of behavioral, pharmacological, and functional neuroimaging studies.
Recent Representative Publications
Wang L, Mullette-Gillman O, Gadde KM, Kuhn CM, McCarthy G & Huettel SA (2009, In Press). The effect of acute tryptophan depletion on emotional distraction and subsequent memory. Social Cognitive and Affective Neuroscience.
Dolcos F, Diaz-Granados P, Wang L & McCarthy G (2008). Opposing influences of emotional and non-emotional distracters upon sustained prefrontal cortex activity during a delayed-response working memory task. Neuropsychologia. 46(1): 326-35.
Wang L, Krishnan KR, Steffens DC, Potter GG, Dolcos F & McCarthy G (2008). Depressive State- and Disease-Related Alterations in Neural Responses to Affective and Executive Challenges in Geriatric Depression. The American Journal of Psychiatry. 165: 863-871.
Wang L, LaBar KS, Smoski M, Rosenthal MZ, Dolcos F, Lynch TR, Krishnan KR & McCarthy G (2008). Prefrontal mechanisms for executive control over emotional distraction are altered in major depression. Psychiatry Research: Neuroimaging. 163(2): 143-155.
Wang L, Huettel SA & De Bellis MD (2008). Neural Substrates for Processing Task-irrelevant Sad Images in Adolescents. Developmental Science. 11(1): 23-32.
Petrella JR, Prince SE, Wang L, Hellegers C & Doraiswamy PM (2007). Prognostic Value of Posteromedial Cortex Deactivation in Mild Cognitive Impairment. PLoS ONE. 2(10): e1104.
Petrella JR, Wang L, Krishnan S, Slavin MJ, Prince SE, Tran TT & Doraiswamy PM (2007). Cortical Deactivation in Mild Cognitive Impairment: A High-Field fMRI Study. Radiology. 245(1): 225-35.
Robertson B, Wang L, Diaz MT, Aiello M, Gersing K, Beyer J, Mukundan S Jr, McCarthy G & Doraiswamy PM (2007). Effect of bupropion extended release on negative emotion processing in major depressive disorder: a pilot functional magnetic resonance imaging study. The Journal of Clinical Psychiatry. 68(2): 261-7.
Wang L, LaBar KS & McCarthy G (2006). Mood alters amygdala activation to sad distractors during an attentional task. Biological Psychiatry. 60(10): 1139-46.
Dolcos F, Kragel P, Wang L & McCarthy G (2006). Role of the inferior frontal cortex in coping with distracting emotions. NeuroReport. 17(15): 1591-4.
Li M, Kuroiwa Y, Wang L, Kamitani T, Omoto S, Hayashi E, Takahashi T, Suzuki Y, Koyano S, Ikegami T & Matsubara S (2005). Visual event-related potentials under different interstimulus intervals in Parkinson's disease: relation to motor disability, WAIS-R, and regional cerebral blood flow. Parkinsonism & Related Disorders. 11(4): 209-19.
Wang L, McCarthy G, Song AW & LaBar KS (2005). Amygdala activation to sad pictures during high-field (4T) functional magnetic resonance imaging. Emotion. 5(1): 12-22.
Li M, Kuroiwa Y, Wang L, Kamitani T, Takahashi T, Suzuki Y & Omoto S (2003). Early sensory information processes are enhanced on visual oddball and S1-S2 tasks in Parkinson's disease: a visual event-related potentials study. Parkinsonism & Related Disorders. 9(6): 329-40.
Kamitani T, Kuroiwa Y, Wang L, Li M, Ikegami T & Matsubara S (2003). Event-related potentials during visual S1-S2 paradigm in multiple system atrophy: relation to morphologic changes on brain MRI measurement. Parkinsonism & Related Disorders. 10(2): 93-100.
Wang L, Kaneoke Y & Kakigi R (2003). Spatiotemporal separability in the human cortical response to visual motion speed: a magnetoencephalography study. Neuroscience Research. 47(1): 109-16.
Kamitani T, Kuroiwa Y, Wang L, Li M, Suzuki Y, Takahashi T, Ikegami T & Matsubara S (2002). Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-P. Journal of Neurology. 249(8): 975-82.
Wang L, Kuroiwa Y, Li M, Wang J & Kamitani T (2001). Do P1 and N1 evoked by the ERP task reflect primary visual processing in Parkinson's disease?. Documenta Ophthalmologica: Advances in Ophthalmology. 102(2): 83-93.
Wang L, Kakigi R & Hoshiyama M (2001). Neural activities during Wisconsin Card Sorting Test--MEG observation. Cognitive Brain Research. 12(1): 19-31.
Wang L, Barber C, Kakigi R, Kaneoke Y, Okusa T & Wen Y (2001). A first comparison of the human multifocal visual evoked magnetic field and visual evoked potential. Neuroscience Letters. 315(1-2): 13-6.
Wang L, Kuroiwa Y, Li M, Kamitani T, Wang J, Takahashi T, Suzuki Y, Ikegami T & Matsubara S (2000). The correlation between P300 alterations and regional cerebral blood flow in non-demented Parkinson's disease. Neuroscience Letters. 282(3): 133-6.
Wang L, Kuroiwa Y, Kamitani T, Li M, Takahashi T, Suzuki Y, Shimamura M & Hasegawa O (2000). Visual event-related potentials in progressive supranuclear palsy, corticobasal degeneration, striatonigral degeneration, and Parkinson's disease. Journal of Neurology. 247(5): 356-63.