Functional Magnetic Resonance Imaging
NEUROBIO 381
Fall 2003
Computers for lab exercises are available in rooms 251 and 166.
Departments of Psychiatry, Neurobiology, and Psychology
Brain Imaging and Analysis Center (Bell 254D)
email: phone: 681-9527
Given the size of the class, office hours will be by appointment.
Course Information
This course is intended to provide a comprehensive and rigorous introduction to the technique of functional magnetic resonance imaging (fMRI). Students will learn the basic physics underlying MRI, the biological principles of fMRI, the principles of experimental design, the processing steps associated with data analysis, and the use of available software packages. Each week’s session will be composed of a lecture and laboratory. Each part will be led by one or more BIAC faculty members. Where possible, the laboratory topics will be flexible so that students with more experience can explore the issues covered in more detail.
As this is a graduate course, grades will reflect a certification of training, rather than a competition between students. Therefore, all grades can be raised to “E” by demonstrating understanding of the material. Grades will be based on participation in course sessions, completion of laboratory exercises, weekly short answer questions, and a final practicum research project. There may also be one take-home test. All assignments are primarily pedagogical, not evaluative.
Auditors are welcome (and encouraged) to take the course, but regular attendance and participation is required. Auditors will be expected to complete the same assignments as the students, or they will not be allowed to participate in the course.
Course web page: http://www.biac.duke.edu/education/courses/
Course Outline
Please note: you must have a BIAC login to access the readings. We apologize for the inconvenience. Also, additional readings and lecture notes will appear here as the semester progresses. If you want a printed copy of the handouts, we recommend opening the Powerpoint version and selecting Print As: Handout from the Print dialog. This will save ink and paper.
|
8/27 |
Lecture: |
Introduction
to fMRI (html) (powerpoint) |
Huettel |
|
|
Laboratory: |
Visit to MR Scanner, Real-time fMRI |
Voyvodic |
|
|
|
CH 1
(self-assessment) |
|
|
9/3 |
Lecture: |
From Neuronal to
Hemodynamic Activity (html) (powerpoint) |
McCarthy |
|
|
Laboratory: |
Exploring
Brain Anatomy (exercises) |
|
|
|
|
CH 2
(self-assessment) |
|
|
9/10 |
Lecture:
|
MR Physics: Basic
Principles (html) (powerpoint) |
Song |
|
|
Laboratory: |
Matlab
and BIAC tools (exercises) |
|
|
|
|
CH 3
(self-assessment) |
|
|
9/17
|
Lecture: |
MR Physics: Image
Formation (html) (powerpoint) |
Song |
|
|
Laboratory: |
Understanding
K-Space (exercises) |
|
|
|
|
CH 4
(self-assessment) |
|
|
9/24 |
Lecture: |
MR Physics: Pulse
Sequences and Contrast
(html) (powerpoint) |
Song |
|
|
Laboratory: |
Working
with fMRI datasets (exercises) |
|
|
|
|
CH 5
(self-assessment) |
|
|
10/1 |
Lecture: |
BOLD fMRI Imaging (html) (powerpoint) |
Huettel |
|
|
Laboratory: |
Working
with fMRI datasets, cont. |
|
|
|
|
CH 6
(self-assessment) |
|
|
10/8 |
Lecture:
|
Spatial and Temporal
Resolution (html) (powerpoint) |
Huettel |
|
|
Laboratory: |
Working
with fMRI datasets, cont. |
|
|
|
|
CH 7
(self-assessment) |
|
|
10/15 |
Lecture: |
Signal and Noise
Properties (html) (powerpoint) |
Huettel |
|
|
Laboratory: |
Effects
of Trial Averaging (exercises) |
|
|
|
|
CH 8
(self-assessment) |
|
|
10/22 |
Lecture: |
Data preprocessing, Basic
Design (html) (powerpoint) |
Huettel |
|
|
Laboratory: |
Effects
of Trial Averaging, cont. |
|
|
|
|
CH 9
(self-assessment), CH 10 (self-assessment) |
|
|
10/29 |
Lecture: |
Experimental Analysis,
Advanced Design (html) (powerpoint) |
Huettel |
|
|
Laboratory: |
Effects
of Temporal Sampling (exercises) |
|
|
|
|
CH 10
(self-assessment), CH 11 (self-assessment) |
|
|
11/5 |
Lecture: |
Integrating fMRI with
other Techniques |
McCarthy |
|
|
Laboratory:
|
Class
project analysis |
|
|
|
|
CH 13 (self-assessment), CH 14 |
|
|
11/12 |
Lecture: |
Advanced fMRI |
Song |
|
|
Laboratory: |
Class
project analysis |
|
|
|
|
CH 12 (self-assessment) |
|
|
11/19 |
Lecture: |
Clinical fMRI and its
Implications |
Voyvodic |
|
|
Laboratory: |
Class
project analysis |
|
|
|
|
To be announced |
|